Table 2 Examples of gene loci associated with T2DM, Hypothyroidism and related traits
Gene locus | Full gene name | SNP | Associated phenotype | Odds ratio (95% CI) | p-value | Reference |
|---|---|---|---|---|---|---|
PPARG | Peroxisome proliferator-activated receptor gamma | rs1801282 | T2DM | 1.14 (1.08-1.20) | 1.7 × 10-6 | Scott et al[44]. |
KCNJ11 | Potassium inwardly rectifying channel, subfamily J, member 11 | rs5219 | T2DM | 1.14 (1.10-1.19) | 6.7 × 10-11 | Scott et al[44]. |
TCF7L2 | Transcription factor 7-like 2 | rs7903146 | T2DM, glucose, HbA1c | 1.37 (1.31-1.43) | 1.0 × 10-8 | Sladek et al[45]. |
rs12255372 | ||||||
SLC30A8 | Solute carrier family 30 [zinc transporter], member 30 | rs13266634 | T2DM, HbA1c | 1.12 (1.07-1.16) | 5.3 × 10-8 | Zeggini et al[46]. |
FTO | Fat mass and obesity associated | rs8050136 | T2DM, BMI | 1.17 (1.12-1.22) | 1.3 × 10-12 | Scott et al[44]. |
FOXE1 | Forkhead box protein E1 | rs965513 | Thyroid cancer, TSH levels | 1.75 (1.49-2.01) | 1.7 × 10-27 | Gudmundsson et al[18]. |
FOXE1 | Forkhead box protein E1 | rs7850258 | Hypothyroidism | 0.74 (0.67-0.82) | 3.96 × 10-9 | Denny et al[47]. |
PTPN22 | Protein tyrosine phosphatase, non-receptor type 22 | rs2476601 | Hashimoto’s thyroiditis | 1.77 (1.31-2.40) | 4.6 × 10-13 | Criswell et al[20]. |
VAV3 | Guanine nucleotide exchange factor | rs4915077 | Hypothyroidism | 1.397 (1.27-1.54) | 8.3 × 10-11 | Eriksson et al[48]. |