Enrichment analysis applied to disease prognosis

Table 3 Top 10 enriched biological process terms in the profiling analysis of SCD patients

Acc	Name	p-value	p-Bonf	SFreq	PFreq
GO:0030049	Muscle filament sliding	7.7E-40	4.1E-38	94%	0.21%
GO:0033275	Actin-myosin filament sliding	7.7E-40	4.1E-38	94%	0.21%
GO:0055010	Ventricular cardiac muscle tissue morphogenesis	7.7E-40	4.1E-38	94%	0.21%
GO:0003229	Ventricular cardiac muscle tissue development	2.4E-39	1.3E-37	94%	0.22%
GO:0070252	Actin-mediated cell contraction	6.8E-39	3.6E-37	94%	0.24%
GO:0002027	Regulation of heart rate	1.3E-31	6.9E-30	81%	0.26%
GO:0007512	Adult heart development	6.8E-25	3.6E-23	56%	0.07%
GO:0032781	Positive regulation of ATPase activity	2.9E-15	1.5E-13	38%	0.09%
GO:0043462	Regulation of ATPase activity	2.6E-14	1.4E-12	38%	0.12%
GO:0032971	Regulation of muscle filament sliding	1.0E-12	5.4E-11	25%	0.02%

The terms shown are the 10 biological process terms with the lowest p-value, obtained in the profiling of SCD patients. For each term is indicated: GO accession number (Acc), term name, p-value without multiple-testing correction, p-value with Bonferroni correction (p-Bonf), annotation frequency in the study set (SFreq) and annotation frequency in the population set (PFreq).

ISSN: 2041-1480