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Table 6 Enriched terms in the profiling analysis of no-SCD patients, not identified in the SCD patients

From: Enrichment analysis applied to disease prognosis

Acc

Name

p-value

p-Bonf

SFreq

PFreq

 

Biological process

   

GO:0001980

Regulation of systemic arterial blood

6.0E-41

4.4E-39

13%

0.00

 

pressure by ischemic conditions

    

GO:0001976

Neurological system process involved in regulation

3.4E-25

2.5E-23

13%

0.00

 

of systemic arterial blood pressure

    

GO:0006940

Regulation of smooth muscle contraction

6.6E-19

4.9E-17

13%

0.00

GO:0007522

Visceral muscle development

5.3E-03

3.9E-01

1%

0.00

GO:0042694

Muscle cell fate specification

5.3E-03

3.9E-01

1%

0.00

GO:0055009

Atrial cardiac muscle tissue morphogenesis

2.6E-02

1.9E+00

1%

0.00

GO:0003228

Atrial cardiac muscle tissue development

2.6E-02

1.9E+00

1%

0.00

GO:0048739

Cardiac muscle fiber development

4.2E-02

3.1E+00

1%

0.00

GO:0042693

Muscle cell fate commitment

5.7E-02

4.2E+00

1%

0.00

 

Molecular function

   

GO:0031014

Troponin T binding

9.9E-33

7.3E-31

13%

0.00

GO:0019855

Calcium channel inhibitor activity

1.9E-31

1.4E-29

13%

0.00

GO:0008200

Ion channel inhibitor activity

1.4E-23

1.0E-21

13%

0.00

GO:0016248

Channel inhibitor activity

1.4E-23

1.0E-21

13%

0.00

GO:0005246

Calcium channel regulator activity

4.9E-23

3.6E-21

13%

0.00

GO:0048306

Calcium-dependent protein binding

1.1E-19

8.1E-18

13%

0.00

GO:0042805

Actinin binding

5.6E-06

4.2E-04

4%

0.00

GO:0030899

Calcium-dependent ATPase activity

1.6E-02

1

1%

0.00

GO:0003785

Actin monomer binding

7.2E-02

1

1%

0.00

  1. The terms shown are the biological process and molecular function terms identified as enriched in the profiling analysis of no-SCD patients that were not identified in the profiling of SCD patients. For each term is indicated: GO accession number (Acc), term name, p-value without multiple-testing correction, p-value with Bonferroni correction (p-Bonf), annotation frequency in the study set (SFreq) and annotation frequency in the population set (PFreq).