Using OWL reasoning to support the generation of novel gene sets for enrichment analysis

Table 1 Results table for RCV cannabinoid

GO name	GO ID	manual	auto	checked
regulation of endocannabinoid signaling pathway	GO 2000124	1	1	1
cannabinoid signaling pathway	GO 0038171	1	1	1
endocannabinoid signaling pathway	GO 0071926	1	0	1
cannabinoid receptor activity	GO 0004949	0	1	1
cannabinoid biosynthetic process	GO 1901696	0	1	1

The table shows the mapping of an RCV term“cannabinoid” to a set of GO terms, comparing manual mapping (manual column) with automated mapping (auto column). The automated mapping results from an OWL query for processes in which a cannabinoid participates, or that regulates a process in which a cannabinoid participates. The automated mapping found three additional GO terms compared to the manual mapping. In this case, no manually mapped terms were obsolete in GO and all automated mappings were approved

ISSN: 2041-1480