Supporting shared hypothesis testing in the biomedical domain

Table 7 Causalities we can prove (> 50% confidence), as we add more knowledge, and which we cannot prove with our restricted knowledge of causality relationships

Source s	Target t	\(C_{s}^{t} (\mathcal {E}_{sub})\) for H_broader	\(C_{s}^{t} (\mathcal {E}_{sub})\) for H_sub
Cartilage calcification	Positive regulation of TNF	0.60	0.0
	alpha overproduction
Diminution of load bearing	Biochemical imbalance	0.57	0.0
capacity of cartilage	Negative regulation of	0.60	0.0
	Chondrocytes anabolic activity
	Negative regulation of	0.60	0.0
	Collagen production
	Negative regulation of	0.60	0.0
	Proteoglycan production
	Positive regulation of Chondrocytes	0.60	0.0
	catabolic activity
	Positive regulation of TNF	0.75	0.0
	alpha overproduction
	Synovial inflammation	0.66	0.0
Meniscal tear	Biochemical imbalance	0.57	0.0
	Negative regulation of	0.60	0.0
	Collagen production
	Negative regulation of	0.60	0.0
	Proteoglycan production
	Positive regulation of Chondrocytes	0.60	0.0
	catabolic activity
	Positive regulation of TNF	0.75	0.0
	alpha overproduction
Water content increase	Positive regulation of TNF	0.60	0.0
in cartilage	alpha overproduction

ISSN: 2041-1480