Study | Subjects | Method | Result/Conclusion |
---|---|---|---|
Casamenti et al. [61] | Adult male Wistar rats | IL-1 beta injected into nucleus basalis; microdialysis | Significant increase in glutamate |
Prow and Irani [62] | Spinal cord tissue extracted from mice challenged with neuroadapted Sindbis virus | Immunoblotting and immunohistochemistry, cytokine assays, and histological analysis | Increase of IL-1 beta in response to the virus disrupts glutamate homeostasis (development of excitotoxicity) |
Fogal et al. [63] | IL-1RI null mutant, mGluR1-/-, and wild-type control mice | Both in vitro and in vivo experiments | IL-1 beta increases extracellular glutamate as part of the mechanism of neuronal injury |
Yan and Weng [64] | Young adult male Sprague-Dawley rats | In vitro and in vivo techniques to study experimentally induced neuropathic pain | IL-1 beta enhances glutamate release from primary afferents |
Yan et al. [65] | Tissue from young adult male Sprague-Dawley rats subjected to partial sciatic nerve ligation | Several in vitro techniques | IL-1 beta contributes to neuropathic pain by suppressing glial glutamate uptake |