Table 1 Disease-related definitions extracted and/or modified from the BFO-based Ontology of General Medical Science (OGMS) 25 and other sources
Generic Term | Level of reality | Type | Definition |
|---|---|---|---|
B odily C omponent | L1 | IC | M aterial O bject within or on the surface of an O rganism, including A natomical S tructures, body flora, pathogens, toxins, and their combinations, potentially including also the organism as a whole [25, 32] |
B odily F eature | L1 | POR | B odily C omponent, B odily Q uality, or B odily P rocess [25] |
B odily P rocess | L1 | O | P rocess in which at least one B odily C omponent of an O rganism participates[25] |
B odily Q uality | L1 | DC | Q uality inhering in a B odily C omponent [25] |
C linical P henotype | L1 | POR | a clinically abnormal P henotype [25] |
C linical P icture | L2/L3 | POR | a R epresentation of a c linical p henotype that is inferred from the combination of laboratory, image and clinical findings about a given O rganism [25]. |
D iagnosis | L2/L3 | DC | R epresentation asserting the presence of an instance of D isease in a given O rganism resulting from an interpretive process that has as input a c linical p icture of that O rganism [25] |
D isease | L1 | DC | a D isposition (i) to undergo P athological P rocesses that (ii) exists in an O rganism because of one or more d isorders in that O rganism [25] |
D isease C ourse | L1 | O | the totality of all P rocesses through which a given D isease instance is realized[25] |
D isease P henotype | L1 | POR | a C linical P henotype that is characteristic of a single D isease [25] |
D isorder | L1 | IC | A combination of B odily C omponents of or in an O rganism that is clinically abnormal [25, 41] |
O bservation | L2 | DC | C ognitive R epresentation about a B odily F eature resulting from an act of perception [42] |
P athological P rocess | L1 | O | a B odily P rocess that is a manifestation of a D isorder [25] |
P henotype | L1 | POR | a combination of one or more B odily F eatures of an O rganism determined by the interaction of its genetic make-up and environment [25] |