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Table 1 Predicted 32 genes related to IFN-γ and vaccine networks.

From: Mining of vaccine-associated IFN-γ gene interaction networks using the Vaccine Ontology

Gene Degree Eigenvector Betweenness Closeness Reference (PMID)
IL2 + + + + 8459207
TNF + + + + 16446013
IL10 + + + + 10930151
IL6 + + + + 10225849
IL4 + + + + 8519092
CSF2 + + + + 19459853
IL8 + + + + 11378044
IL5 + + - + 11138639
NFKB1 * + + + + 16971487
IL13 + + + + 12232042
CD4 + + + + 17298856
TLR2 * + + + - 12874299
IL7 + - + + 17496983
IL18 + - - + 19467215
EIF2AK2 + + + - 19596385
CD40LG + + + + 11403919
CD40 + + - - 11403919
CD28 + + - - 12594842
C3 + + + - 19477524
TLR4 ** + - - - 12874299
TP53 ** - + - - 10379742
FCGR2B ** - + - - 12874345
CD46 - + + - 11757799
NCAM1 * - - + + 16316416
CXCL10 * - - + - 10799249
CD86 * - - + - 12594842
HSPD1 - - + - 12218165
IFNA1 - - - + 19667099
CCL2 * - - - + 19833737
TPBG - - - + 16630022
GNLY - - - + 10644038
CD8A - - - + 18425263
  1. These genes were ranked among the top 20 by at least one of the centrality measures in the literature-mined IFN-γ and vaccine network using VO (i.e. IFNG-vaccine-VO network). The sign “+” means that a gene is ranked among top 20 with the corresponding centrality measure. The sign “-” indicates the opposite. Genes marked with * were not ranked high in the IFNG-vaccine network built without using the VO (i.e. IFNG-vaccine network). Genes marked with ** were not found in the IFNG-vaccine network. The PubMed PMIDs are listed to affirm that the associations mined are verified by literature.