Mining of vaccine-associated IFN-γ gene interaction networks using the Vaccine Ontology

Table 1 Predicted 32 genes related to IFN-γ and vaccine networks.

Gene	Degree	Eigenvector	Betweenness	Closeness	Reference (PMID)
IL2	+	+	+	+	8459207
TNF	+	+	+	+	16446013
IL10	+	+	+	+	10930151
IL6	+	+	+	+	10225849
IL4	+	+	+	+	8519092
CSF2	+	+	+	+	19459853
IL8	+	+	+	+	11378044
IL5	+	+	-	+	11138639
NFKB1 *	+	+	+	+	16971487
IL13	+	+	+	+	12232042
CD4	+	+	+	+	17298856
TLR2 *	+	+	+	-	12874299
IL7	+	-	+	+	17496983
IL18	+	-	-	+	19467215
EIF2AK2	+	+	+	-	19596385
CD40LG	+	+	+	+	11403919
CD40	+	+	-	-	11403919
CD28	+	+	-	-	12594842
C3	+	+	+	-	19477524
TLR4 **	+	-	-	-	12874299
TP53 **	-	+	-	-	10379742
FCGR2B **	-	+	-	-	12874345
CD46	-	+	+	-	11757799
NCAM1 *	-	-	+	+	16316416
CXCL10 *	-	-	+	-	10799249
CD86 *	-	-	+	-	12594842
HSPD1	-	-	+	-	12218165
IFNA1	-	-	-	+	19667099
CCL2 *	-	-	-	+	19833737
TPBG	-	-	-	+	16630022
GNLY	-	-	-	+	10644038
CD8A	-	-	-	+	18425263

These genes were ranked among the top 20 by at least one of the centrality measures in the literature-mined IFN-γ and vaccine network using VO (i.e. IFNG-vaccine-VO network). The sign “+” means that a gene is ranked among top 20 with the corresponding centrality measure. The sign “-” indicates the opposite. Genes marked with * were not ranked high in the IFNG-vaccine network built without using the VO (i.e. IFNG-vaccine network). Genes marked with ** were not found in the IFNG-vaccine network. The PubMed PMIDs are listed to affirm that the associations mined are verified by literature.

ISSN: 2041-1480