Keyword semantic enrichment. For a literature search about the regulation of fatty acid metabolic process, we want to enrich the query with the associated genes. The two genes PPAR and CAV1 are directly annotated by the GO term “Regulation of fatty acid metabolic process” (GO:0019217). However, Gene Ontology inheritance properties say that every term inherits the meaning of all its ancestors. Consequently, genes annotated by at least one descendant of the original term (BRCA1, ChREBP and APOA1) should also be considered.