Enrichment analysis applied to disease prognosis

Table 4 Top 10 enriched molecular function terms in the profiling analysis of SCD patients

Acc	Name	p-value	p-Bonf	SFreq	PFreq
GO:0008307	Structural constituent of muscle	2.9E-35	1.6E-33	88%	0.25%
GO:0030898	Actin-dependent ATPase activity	1.1E-26	6.1E-25	56%	0.05%
GO:0000146	Microfilament motor activity	1.8E-23	9.4E-22	56%	0.11%
GO:0032036	Myosin heavy chain binding	3.3E-11	1.8E-09	25%	0.04%
GO:0001671	ATPase activator activity	9.1E-11	4.8E-09	25%	0.05%
GO:0031432	Titin binding	2.1E-10	1.1E-08	25%	0.06%
GO:0060590	ATPase regulator activity	4.0E-10	2.1E-08	25%	0.07%
GO:0017022	Myosin binding	7.6E-09	4.0E-07	25%	0.14%
GO:0030172	Troponin C binding	5.3E-06	2.8E-04	13%	0.02%
GO:0031013	Troponin I binding	8.4E-06	4.4E-04	13%	0.03%

The terms shown are the 10 molecular function terms with the lowest p-value, obtained in the profiling of SCD patients. For each term is indicated: GO accession number (Acc), term name, p-value without multiple-testing correction, p-value with Bonferroni correction (p-Bonf), annotation frequency in the study set (SFreq) and annotation frequency in the population set (PFreq).

ISSN: 2041-1480