Figure 3

Mock up of whole-body treemap schematic depicting a multi-organ endocrine pathway consiting of interlinked FTU-level molecular networks. Figure 1D is extended to depict a number of primary tissue motifs representing FTUs involved in the endocrine regulation of electrolyte and blood pressure levels during exercise. Every individual motif is labeled (in blue – see below for key to label abbreviations). In this mockup of an ApiNATOMY[9] schematic, nesting of one box within another represents the part_of relation such that: (i) tiles representing motifs are nested within tiles representing the anatomical region of origin for the tissue material from which the FTU was acquired, and (ii) tiles representing the constitutent cells of the motif are nested within the corresponding motif tile. The position of nodes in the treegraph overlaid onto the treemap depicts the location of substances (i.e. molecules or charged atoms), with respect to the motif constituents, as follows: a node within the boundary of a cell tile represents an intracellular substance; on the boundary of a cell tile represent a molecule tethered to the plasma membrane of that cell; outside all cell boundaries represents a substance located in the extracellular tissue fluid of the corresponding FTU. TISSUE MOTIF LABELS: [LGIN: Large Intestine; SMIN: Small Intestine; LIVR: Liver; STMC: Stomach; ADRC: Adrenal Cortices; HART: Heart; ARTL: Arterioles; BLOD: Blood; LUNG: Lungs; KDNY: Kidneys; ADRM: Adrenal Medullae; CORD: Spinal Cord; MEDL: Medulla Oblongata; PITR: Pituitary; SKLM: Skeletal Muscles; SWET: Sweat Glands]. EDGE COLOUR: [Black: Molecular Binding; Blue: Intercompartmental Translocation].