The ontology of genetic susceptibility factors (OGSF) and its application in modeling genetic susceptibility to vaccine adverse events

Table 1 Statistical summary of genetic susceptibility factors with systemic adverse event following smallpox vaccination

GSF^&	Allele	Gene	Odds ratio (confidential interval)	P-value	Study 1 or 2
rs1801133 SNP	T	MTHFR	2.3 (1.1–5.2)	0.04	1
rs1801133 SNP	T	MTHFR	4.1 (1.4–11.4)	0.01	2
rs9282763 SNP	G	IRF1	3.2 (1.1–9.8)	0.03	1
rs9282763 SNP	G	IRF1	3.0 (1.1–8.3)	0.03	2
rs839 SNP	A	IRF1	3.2 (1.1–9.8)	0.03	1
rs839 SNP	A	IRF1	3.0 (1.1–8.3)	0.03	2
Haplotype 1*	G,A	IRF1	3.2 (1.0–10.2)	0.03	1
Haplotype 1*	G,A	IRF1	3.0 (1.0–9.0)	0.03	2
Haplotype 2^#	T,C,A	IL4	2.4 (1.0–5.7)	0.05	1
Haplotype 2^#	T,C,A	IL4	3.8 (1.0–14.4)	0.06^$	2

Notes:
^&GSF stands for Genetic Susceptibility Factor.
*Haplotype 1 contains G allele of rs9282763, and A allele of rs839 in IRF1 gene.
^#Haplotype 2 contains T allele of rs2070874, C allele of rs2243268, and A allele of rs2243290 in IL4 gene.
^$In the second study, Haplotype 2 didn’t achieve the significant level of p value.
The data of this table is summarized and curated from Reif. et al.’s work on the genetic analysis of adverse event after smallpox vaccination [37].

ISSN: 2041-1480