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Table 1 Statistical summary of genetic susceptibility factors with systemic adverse event following smallpox vaccination

From: The ontology of genetic susceptibility factors (OGSF) and its application in modeling genetic susceptibility to vaccine adverse events

GSF& Allele Gene Odds ratio (confidential interval) P-value Study 1 or 2
rs1801133 SNP T MTHFR 2.3 (1.1–5.2) 0.04 1
rs1801133 SNP T MTHFR 4.1 (1.4–11.4) 0.01 2
rs9282763 SNP G IRF1 3.2 (1.1–9.8) 0.03 1
rs9282763 SNP G IRF1 3.0 (1.1–8.3) 0.03 2
rs839 SNP A IRF1 3.2 (1.1–9.8) 0.03 1
rs839 SNP A IRF1 3.0 (1.1–8.3) 0.03 2
Haplotype 1* G,A IRF1 3.2 (1.0–10.2) 0.03 1
Haplotype 1* G,A IRF1 3.0 (1.0–9.0) 0.03 2
Haplotype 2# T,C,A IL4 2.4 (1.0–5.7) 0.05 1
Haplotype 2# T,C,A IL4 3.8 (1.0–14.4) 0.06$ 2
  1. Notes:
  2. &GSF stands for Genetic Susceptibility Factor.
  3. *Haplotype 1 contains G allele of rs9282763, and A allele of rs839 in IRF1 gene.
  4. #Haplotype 2 contains T allele of rs2070874, C allele of rs2243268, and A allele of rs2243290 in IL4 gene.
  5. $In the second study, Haplotype 2 didn’t achieve the significant level of p value.
  6. The data of this table is summarized and curated from Reif. et al.’s work on the genetic analysis of adverse event after smallpox vaccination [37].