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Table 8 Best corresponding classes in ATC and MeSH for 13 clinically relevant drug classes

From: A framework for assessing the consistency of drug classes across sources

DDI class

ATC class

MeSH class

Drugs common

Drugs only in ATC

Drugs only in MeSH

ES.

IS

Rel.

Triptans

Selective serotonin (5HT1) agonists

Tryptamines

7

0

1

0.82

-1

Eq

Proton pump inhibitors

Proton pump inhibitors

2-Pyridinylmethylsulfinyl-benzimidazoles

5

1

0

0.76

1

Eq

HMG CoA reductase inhibitors

HMG CoA reductase inhibitors

Hydroxymethylglutaryl-CoA Reductase Inhibitors

8

0

2

0.76

-1

Eq

Tricyclic antidepressants

Non-selective monoamine reuptake inhibitors

Antidepressive agents, Tricyclic

10

2

2

0.69

0

Eq

Protease inhibitors

Protease inhibitors

HIV Protease inhibitors

8

3

1

0.63

0.44

Eq

Narcotic analgesics

OPIOIDS

Narcotics

15

3

11

0.50

-0.48

Eq

Selective serotonin reuptake inhibitors (SSRIs)

Selective serotonin reuptake inhibitors

Serotonin uptake inhibitors

6

0

8

0.40

-1

In

MAO inhibitors

Monoamine oxidase inhibitors, non-selective

Monoamine oxidase inhibitors

3

0

5

0.32

-1

In

Macrolides

Macrolides

Macrolides

8

0

21

0.26

-1

In

Azoles

Imidazole and triazole derivatives

Azoles

11

1

147

0.07

-0.90

In

Amphetamine derivatives

-

-

     

-

Ergot alkaloids and derivatives

-

-

     

-

QT prolonging agents

-

-

     

-

  1. Best corresponding classes in ATC and MeSH for 13 clinically relevant drug classes, with the equivalence (ES) and inclusion (IS) scores from our framework’s metrics, and the relation, equivalence or inclusion, between the two classes (Rel).