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Table 2 Coverage of AERS drugs by NDF-RT classes

From: Standardizing adverse drug event reporting data

Drug_class_type1

Drug_class, No.2

RxNormConcept, No. in the AERS3

a%4

b%5

Generic Ingredient Combinations

26

9,813

96

88

Chemical Ingredients Class

16

9,331

91

81

Therapeutic Intent

24

8,069

79

78

Mechanism of Action

7

8,061

79

81

Physiologic Effect

16

7,989

78

82

VA Class

29

5,823

57

77

FDA Established Pharmacologic Class (EPC)

66

3,049

30

46

Therapeutic Category

7

2,880

28

50

Pharmacokinetics

1

730

7

28

Total

192

10,221

100

100

  1. 1“Drug_class_type” represents various classes provided by NDF-RT as shown in Figure 2.
  2. 2“Drug_Class, No.” is the number of direct subordinate classes of each Drug_class_type.
  3. 3“RxNorm concept, No. in the AERS” shows the total number of RxNorm concepts in the AERS for each drug class type.
  4. 4“a%” indicates the percentage of classified RxNorm concepts for each Drug_class_type, calculated as the division of “RxNorm concept, No. in the AERS” by 10,221; a total of RxNorm concepts mapped to at least one NDF-RT class.
  5. 5“b%” indicates the percentage of classified AERS reports, calculated as the division of the number of AERS reports assigned with the Drug_class_type by the total AERS report number (2,643,979).