Figure 3

Demonstration of restructured CLO cell line cell hierarchy and the application of reasoning. (A) asserted HeLa cell hierarchy. Five intermediate terms between ‘immortal cell line cell’ and ‘HeLa cell’ have been generated in CLO. (B) The SubClass axioms of ‘HeLa cell’. (C) Part of an inferred CLO hierarchy. Compared to the asserted hierarchy in Figure 3A, the term ‘immortal human uterine cervix-derived epithelial cell line cell’ has been inferred as a subclass of ‘immortal human epithelial cell line cell’. (D) The equivalent class definition for ‘immortal human epithelial cell line cell’. (E) The equivalent class definition for ‘immortal human uterine cervix-derived epithelial cell line cell’. The OntoFox tool [9] was used to generate a subset of CLO that includes HeLa cell-related terms. The screenshots were generated using the Protégé OWL editor. The ELK version 0.3.2 ontology reasoner was used for reasoning.