CLO application in modelling the cell line cell-vaccine/pathogen interactions. As reported in a reference , the live attenuated B. abortus cattle vaccine strain RB51 positively regulated programmed cell death of RAW264.7 cell, a macrophage cell line cell. However, its wild type virulent strain 2308 negatively regulated the programmed cell death. The infected cells underwent different cellular processes after the interaction with the vaccine or pathogen. All the boxes represent instances, labelled by the class they are an instance of.