Figure 2
From: Linking gene expression to phenotypes via pathway information
Three challenges when representing and comparing phenotypes. The diagram illustrates the three challenges that need to be overcome in order to link gene expression and phenotypes using pathways: (A) the integration across the different levels of complexity within an organism, (B) the integration across species, and (C) the frequencies of occurrences of phenotypes (quantification) – purple colour represents individuals possessing phenotype of interest (examples in parentheses taken from Angelman syndrome in OrphaNet)