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Table 3 Reference Set DDI and coverage in NDF-RT and DrugBank

From: Evaluating drug-drug interaction information in NDF-RT and DrugBank

Grp # DDI group description # pairs NDF-RT matches DrugBank matches Object members Precipitant members
3 Amphetamine and derivatives – MAO inhibitors 60 30 (50%) 30 (50%) Dexmethylphenidate, Dextroamphetamine, Methylphenidate, Lisdexamfetamine, Phendimetrazine, Pseudoephedrine, Amphetamine, Benzphetamine, Diethylproprion, Phentermine, Atomoxetine, Methamphetamine Tranylcypromine, Phenelzine, Isocarboxazid, Procarbazine, Selegiline
4 Atazanavir – Proton pump inhibitors (PPIs) 5 5 (100%) 5 (100%) Atazanavir Omeprazole, Lansoprazole, Pantoprazole, Rabeprazole, Esmoprazole
8 Fluoxetine - MOA inhibitors 55 39 (71%) 43 (78%) Fluoxetine, Paroxetine, Citalopram, Escitalopram, Sertraline, Fluvoxamine, Duloxetine, Nefazodone, Desvenlafaxine, Milnacipran, Venlafaxine Tranylcypromine, Phenelzine, Isocarboxazid, Procarbazine, Selegiline
11 Irinotecan – Ketoconazole 23 1 (4%) 5 (22%) Irinotecan Ritonavir, Nelfinavir, Atazanavir, Indinavir, Saquinavir, Amprenavir, Darunavir, Lopinavir, Tipranavir, Fosamprenavir, Clarithromycin, Erythromycin, Telithromycin, Amiodarone, Verapamil, Diltiazem, Ketoconazole, Itraconazole, Fluconazole, Voriconazole, Nefazodone, Aprepitant, Cimetidine
16 Narcotic analgesics – MAO inhibitors 30 25 (83%) 15 (50%) Meperidine, Methadone, Tapentadol, Fentanyl, Tramadol, Dextromethorphan Tranylcypromine, Phenelzine, Isocarboxazid, Procarbazine, Selegiline
22 Ramelteon-fluvoxamine 4 0 (0%) 2 (50%) Ramelteon Fluvoxamine, Amiodarone, Ticlopidine, Ciprofloxacin
23 Rifampin – ritonavir 60 41 (68%) 25 (42%) Bosentan, Rifapentine, Carbamazepine, Rifabutin, Rifampin, St. John’s wort Ritonavir, Nelfinavir, Atazanavir, Indinavir, Saquinavir, Amprenavir, Darunavir, Lopinavir, Tipranavir, Fosamprenavir
25 HMG Co-A reductase inhibitors – protease inhibitors 40 38 (95%) 33 (83%) Simvastatin, Lovastatin Ritonavir, Nelfinavir, Atazanavir, Indinavir, Saquinavir, Amprenavir, Darunavir, Lopinavir, Tipranavir, Clarithromycin, Erythromycin, Telithromycin, Amiodarone, Verapamil, Diltiazem, Tranylcypromine, Phenelzine, Isocarboxazid, Procarbazine, Selegiline
27 Telithromycin – ergot alkaloids and derivatives 60 13 (22%) 35 (58%) Ritonavir, Nelfinavir, Atazanavir, Indinavir, Saquinavir, Amprenavir, Darunavir, Lopinavir, Tipranavir, Clarithromycin, Erythromycin, Telithromycin, Ketoconazole, Itraconazole, Voriconazole Ergotamine, Methylergonovine, Dihydroergotamine, Ergonovine
28 Tizanidine – ciprofloxacin 7 6 (86%) 6 (86%) Tizanidine Fluvoxamine, Amiodarone, Ticlopidine, Ciprofloxacin, Mexiletine, Propafenone, Zileuton
30 Tranylcypromine – procarbazine 1 1 (100%) 1 (100%) Tranylcypromine Procarbazine
31 Triptans – MAO inhibitors 15 8 (53%) 11 (73%) Sumatriptan, Zolmitriptan, Rizatriptan Tranylcypromine, Phenelzine, Isocarboxazid, Moclobamide, Methylene blue
  TOTAL   207 (58%) 211 (59%)