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Table 3 Reference Set DDI and coverage in NDF-RT and DrugBank

From: Evaluating drug-drug interaction information in NDF-RT and DrugBank

Grp #

DDI group description

# pairs

NDF-RT matches

DrugBank matches

Object members

Precipitant members

3

Amphetamine and derivatives – MAO inhibitors

60

30 (50%)

30 (50%)

Dexmethylphenidate, Dextroamphetamine, Methylphenidate, Lisdexamfetamine, Phendimetrazine, Pseudoephedrine, Amphetamine, Benzphetamine, Diethylproprion, Phentermine, Atomoxetine, Methamphetamine

Tranylcypromine, Phenelzine, Isocarboxazid, Procarbazine, Selegiline

4

Atazanavir – Proton pump inhibitors (PPIs)

5

5 (100%)

5 (100%)

Atazanavir

Omeprazole, Lansoprazole, Pantoprazole, Rabeprazole, Esmoprazole

8

Fluoxetine - MOA inhibitors

55

39 (71%)

43 (78%)

Fluoxetine, Paroxetine, Citalopram, Escitalopram, Sertraline, Fluvoxamine, Duloxetine, Nefazodone, Desvenlafaxine, Milnacipran, Venlafaxine

Tranylcypromine, Phenelzine, Isocarboxazid, Procarbazine, Selegiline

11

Irinotecan – Ketoconazole

23

1 (4%)

5 (22%)

Irinotecan

Ritonavir, Nelfinavir, Atazanavir, Indinavir, Saquinavir, Amprenavir, Darunavir, Lopinavir, Tipranavir, Fosamprenavir, Clarithromycin, Erythromycin, Telithromycin, Amiodarone, Verapamil, Diltiazem, Ketoconazole, Itraconazole, Fluconazole, Voriconazole, Nefazodone, Aprepitant, Cimetidine

16

Narcotic analgesics – MAO inhibitors

30

25 (83%)

15 (50%)

Meperidine, Methadone, Tapentadol, Fentanyl, Tramadol, Dextromethorphan

Tranylcypromine, Phenelzine, Isocarboxazid, Procarbazine, Selegiline

22

Ramelteon-fluvoxamine

4

0 (0%)

2 (50%)

Ramelteon

Fluvoxamine, Amiodarone, Ticlopidine, Ciprofloxacin

23

Rifampin – ritonavir

60

41 (68%)

25 (42%)

Bosentan, Rifapentine, Carbamazepine, Rifabutin, Rifampin, St. John’s wort

Ritonavir, Nelfinavir, Atazanavir, Indinavir, Saquinavir, Amprenavir, Darunavir, Lopinavir, Tipranavir, Fosamprenavir

25

HMG Co-A reductase inhibitors – protease inhibitors

40

38 (95%)

33 (83%)

Simvastatin, Lovastatin

Ritonavir, Nelfinavir, Atazanavir, Indinavir, Saquinavir, Amprenavir, Darunavir, Lopinavir, Tipranavir, Clarithromycin, Erythromycin, Telithromycin, Amiodarone, Verapamil, Diltiazem, Tranylcypromine, Phenelzine, Isocarboxazid, Procarbazine, Selegiline

27

Telithromycin – ergot alkaloids and derivatives

60

13 (22%)

35 (58%)

Ritonavir, Nelfinavir, Atazanavir, Indinavir, Saquinavir, Amprenavir, Darunavir, Lopinavir, Tipranavir, Clarithromycin, Erythromycin, Telithromycin, Ketoconazole, Itraconazole, Voriconazole

Ergotamine, Methylergonovine, Dihydroergotamine, Ergonovine

28

Tizanidine – ciprofloxacin

7

6 (86%)

6 (86%)

Tizanidine

Fluvoxamine, Amiodarone, Ticlopidine, Ciprofloxacin, Mexiletine, Propafenone, Zileuton

30

Tranylcypromine – procarbazine

1

1 (100%)

1 (100%)

Tranylcypromine

Procarbazine

31

Triptans – MAO inhibitors

15

8 (53%)

11 (73%)

Sumatriptan, Zolmitriptan, Rizatriptan

Tranylcypromine, Phenelzine, Isocarboxazid, Moclobamide, Methylene blue

 

TOTAL

 

207 (58%)

211 (59%)

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