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Table 6 Top DDI Pairs found in Prescription Data

From: Evaluating drug-drug interaction information in NDF-RT and DrugBank

Drug pair Freq DrugBank DDI NDF-RT DDI
Amlodipine-Simvastatin 76980   X
Glipizide-Metoprolol 15469 X X
atorvastatin-Fenofibrate 14897 X X
Fenofibrate-Simvastatin 14060 X X
Albuterol-Metoprolol 14030 X  
Insulin Glargine-Metoprolol 13492 X  
Metoprolol-Sertraline 13311 X  
atorvastatin-Diltiazem 13218 X X
Digoxin-Furosemide 12958 X  
Lisinopril-Triamterene 12399 X X
cyclobenzaprine-Tramadol 12211 X  
Diltiazem-Metoprolol 11738 X  
Oxycodone-Sertraline 11710 X  
Diltiazem-Simvastatin 11484 X X
Alprazolam-Fluoxetine 11194   X
Sertraline-Trazodone 11066 X  
Amoxicillin-Ethinyl Estradiol 11044 X  
Lisinopril-Spironolactone 10248 X X
Clonazepam-Fluoxetine 10149   X
Fenofibrate-rosuvastatin 9954 X X
Clonidine-Metoprolol 9827 X X
Hydralazine-Metoprolol 9556 X  
duloxetine-Trazodone 9236 X  
clopidogrel-pantoprazole 9177 X  
Escitalopram-Metoprolol 8396 X  
Levofloxacin-Prednisone 8335   X
Escitalopram-Oxycodone 8228 X  
Citalopram-Trazodone 8081 X  
Citalopram-Oxycodone 8016 X  
Metoprolol-salmeterol 7703 X  
Atenolol-Glipizide 7597 X X
Fluoxetine-Trazodone 7579 X  
carvedilol-Digoxin 7517 X  
Fluoxetine-Oxycodone 7508 X  
carvedilol-Insulin Glargine 7496 X  
Citalopram-Metoprolol 7474 X  
Escitalopram-Trazodone 7421 X  
Alprazolam-Omeprazole 7339 X