Table 1 Example sentences with drug enzyme relations from literature
From: Extracting drug-enzyme relation from literature as evidence for drug drug interaction
PMID | Study type | Sentence with drug enzyme interaction |
|---|---|---|
10223773 | in vivo | Rifampin (INN, rifampicin) is a potent inducer of CYP3A4 and some other CYP enzymes. |
11353758 | in vitro | Rifalazil-32-hydroxylation in microsomes was completely inhibited by CYP3A4-specific inhibitors (fluconazole, ketoconazole, miconazole, troleandomycin) and drugs metabolized by CYP3A4 such as cyclosporin A and clarithromycin, indicating that the enzyme responsible for the rifalazil-32-hydroxylation is CYP3A4. |