Table 1 Source contributions of drug-indication data
source abbrev | source name or description | subset if any | version/date | number of drug-indication pairs | ||
|---|---|---|---|---|---|---|
initial | filtered | parsed | ||||
ChEBI | Chemicals of Biological Interest Ontology | has_role relations | 104/June 1, 2013 | 16,415 | 8,598 | 8,598 |
CTD | Comparative Toxicogenomics Database | Chemicals-Diseases Associations,“direct evidence” subset | May 2, 2014 | 82,000 | 81,214 | 81,214 |
DailyMed | NLM’s database of FDA package inserts | single component title (product name) & Indications sections with tractable text length (<540) | March 20, 2011 | 15,834 | 1,612 | 3,840 |
DrugBank | U. Alberta open access DB of drug target and other info | title (drug name) & Indications sections | 3.0/2011 | 1,599 | 1,595 | 6,004 |
MeSH PA | Medical Subject Headings Pharmacologic Action relations | 2013/Dec. 3, 2012 | 26,293 | 25,847 | 25,908 | |
NDFRT | National Drug Formulary Reference Terminology | may_treat & may_prevent relations | 2009AA (UMLS) | 50,775 | 5,294 | 5,294 |
PDR | Physicians’ Desk Reference | Section 3 - Product Category Index | 2006 | 3,150 | 1,204 | 2,169 |
USAN_TC | United States Adopted Names Therapeutic Claims | March 31, 2014 (eVOC) | 6,569 | 5,954 | 7,234 | |
WHO_ATC | World Health Organization Anatomic-Therapeutic-Chemical, Defined Daily Dose index | 2005 | 16,276 | 7,807 | 9,004 | |
WHO_DD | World Health Organization Drug Dictionary | single generic compounds with ATC codes (minus 2005 WHO-ATC overlap and herbals BNA = “9…”) | Sept. 2013 | 40,736 | 21,764 | 25,674 |
evoc_ATC | WHO-ATC codes in Merck’s eVOC generic names dictionary | single generic compounds with ATC codes (minus WHO-ATC & WHO-DD overlap) | May 6, 2014 | 65,552 | 16,269 | 19,093 |