Source description | Drug and HOI mapping method | Distinct drug-HOI pairs in source | Distinct drug-HOI pairs in LAERTES (%) |
---|---|---|---|
Adverse drug reactions mined from US drug product labels using a validated natural language processing tool called SPLICER [29] | Drugs were coded using RxNorm and HOIs using MedDRA. The OMOP Standard Vocabulary was used to map MedDRA to SNOMED-CT. | 272 436a | 254 738 (93%) |
Adverse drug events extracted from EU Summary of Product Characteristics by the PROTECT project | Drugs were mentioned by name and HOIs using MedDRA codes. Drug names were mapped to RxNorm using a combination of simple string matching and Bioportal ontology searches. Many combination products and some individual drugs were not mappable. All mappings were manually reviewed for accuracy. | 26 989 | 24 537 (91%) |
FDA Adverse Event Reporting System counts and Proportional Reporting Ratio from [45] | The OHDSI Usagi tool [46] was used to map drug and HOI mentions to RxNorm and MedDRA. The OMOP Standard Vocabulary was used to map MedDRA coded HOIs to SNOMED-CT. A paper describing the database and mapping method has been published [47]. | 3 766 382 | 2 753 078 (73%) |
Abstracts from titles and abstracts indexed in MEDLINE that describe drug-HOI evidence according to MeSH indexing [48] | Drug and HOI concepts were both coded using MeSH. The OMOP Standard Vocabulary was used to map from MeSH drug concepts to RxNorm and MeSH HOI concepts to SNOMED-CT. | 79 119b | 77 395 (97.8%) |
Sentence spans from titles and abstracts indexed in MEDLINE that describe drug-HOI evidence according to queries against the Semantic Medline database | Drug and HOI concepts were both coded using UMLS concept identifiers. The UMLS Metathesaurus MRCONSO table was used to map concepts to RxNorm, MeSH, MedDRA, and SNOMED-CT. The OMOP standard vocabulary was then used to map drug concepts only available as MeSH to RxNorm and HOI concepts only available as MedDRA or MeSH concepts to SNOMED-CT. | 5 023b | 2 813 (56%) |
Chemical disease associations from the Comparative Toxicogenomics Database | Drug and HOI concepts were both coded using MeSH. The OMOP Standard Vocabulary was used to map from MeSH drug concepts to RxNorm and MeSH HOI concepts to SNOMED-CT. | 503 835 | 432 850 (86%) |