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Table 3 Overlap of distinct drug-HOI pairs at the drug ingredient level after mapping drugs to RxNorm and HOIs to SNOMED-CT

From: Large-scale adverse effects related to treatment evidence standardization (LAERTES): an open scalable system for linking pharmacovigilance evidence sources with clinical data

Literature (MEDLINE and CTD) vs spontaneous reporting (n = 3 049 743)

Product labeling (US and EU) vs spontaneous reporting (n = 2 702 577)

Literature (MEDLINE and CTD) vs product labeling (US and EU) (n = 566 379)

All three (n = 3 057 406)

119 293 (3.9%)

87 279 (3.2%)

14 838 (2.6%)

14 295 (0.5%)

  1. The counts and percentages shown contrast the sum of the union (shown in the heading) and intersection of the distinct drug-HOI pairs from both sources mentioned. CTD: Comparative Toxicogenomics Database, EU: European Union, US: United States
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