Table 1 The most central nodes in the network. The top 10 nodes based on Degree (D), Eigenvector (E), Closeness (C), and Betweenness (B) centrality metrics. The minimum (i.e., top) rank of each node based on any of the four centrality metrics is shown in the Min column

Vaccine gene

fimH

1

1

2

1

1

Vaccine gene

fepA

2

2

1

2

1

E. coli

fimA

3

7

9

6

3

E. coli

ompT

4

4

3

4

3

E. coli

hlyA

5

3

4

-

3

INO

Inclusion

6

5

3

7

3

Vaccine gene

vat

-

-

-

3

3

Vaccine gene

carA

-

-

-

5

5

INO

protein translation

-

-

5

-

5

E. coli

yfcU

8

6

-

-

6

INO

gene expression

9

-

6

10

6

E. coli

entF

7

-

-

-

7

E. coli

chuA

9

8

7

-

7

E. coli

tonB

-

-

-

8

8

INO

dominant regulation

-

-

8

-

8

INO

association

9

9

9

-

9

INO

regulation

9

-

9

-

9

Vaccine gene

carB

-

-

-

9

9

E. coli

hlyD

-

10

-

-

10