Fig. 3

New OAE term generation and annotation using Ontorat. First an ODP was identified to define new AE terms (a). The ODP guided the generation of an Excel template and Ontorat settings. The template file was populated with detailed contents (one row for one new term; only two rows shown in this example) (b). The Ontorat settings were matched to the Excel data format (c). The settings and populated Excel file were then used as Ontorat inputs to generate an OWL format output file containing newly created ontology terms together with their annotations. The output could be displayed using the Protégé OWL editor (d). After merging the output file to existing OAE file, the detailed information of imported ontology terms (e.g., ‘discomfort AE’ OAE_000081) seen in (d) will be obtained from and aligned to existing OAE (e)