Table 1 Characteristics of the two reference sets
From: Using predicate and provenance information from a knowledge graph for drug efficacy screening
Characteristics | Guney reference set | EMC reference set |
|---|---|---|
Source of drug-disease indications | MEDI-HPS + Metab2MeSH + manual curation | MEDI-HPS [23] |
Drug target sets | 238 | 314 |
Unique drug targets | 384 | 539 |
Source of drug targets | DrugBank | Santos et al. [25] |
Disease protein sets | 78 | 281 |
Unique disease proteins | 2726 | 3205 |
Minimum size of disease protein set | 20 | 1 |
Median size of disease protein set | 52 | 5 |
Maximum size of disease protein set | 606 | 273 |
Source of disease proteins | OMIM + GWAS | DisGeNet, curated subset [26] |
Number of positive cases | 402 | 1250 |
Number of negative cases | 18,162 | 86,984 |