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Table 4 Summary of articles discussing IL-1 beta and glutamate (disorder and location not specified in query)

From: Investigating the role of interleukin-1 beta and glutamate in inflammatory bowel disease and epilepsy using discovery browsing

Study Subjects Method Result/Conclusion
Casamenti et al. [61] Adult male Wistar rats IL-1 beta injected into nucleus basalis; microdialysis Significant increase in glutamate
Prow and Irani [62] Spinal cord tissue extracted from mice challenged with neuroadapted Sindbis virus Immunoblotting and immunohistochemistry, cytokine assays, and histological analysis Increase of IL-1 beta in response to the virus disrupts glutamate homeostasis (development of excitotoxicity)
Fogal et al. [63] IL-1RI null mutant, mGluR1-/-, and wild-type control mice Both in vitro and in vivo experiments IL-1 beta increases extracellular glutamate as part of the mechanism of neuronal injury
Yan and Weng [64] Young adult male Sprague-Dawley rats In vitro and in vivo techniques to study experimentally induced neuropathic pain IL-1 beta enhances glutamate release from primary afferents
Yan et al. [65] Tissue from young adult male Sprague-Dawley rats subjected to partial sciatic nerve ligation Several in vitro techniques IL-1 beta contributes to neuropathic pain by suppressing glial glutamate uptake