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Table 5 Summary of articles discussing glutamate and inflammatory bowel disease

From: Investigating the role of interleukin-1 beta and glutamate in inflammatory bowel disease and epilepsy using discovery browsing

Study Subjects Method Result/Conclusion
Clarke et al. [68] Male patients with irritable bowel syndrome and healthy controls High performance liquid chromato-graphy on plasma samples Kynurenic acid was decreased in patients with disease
Varga et al. [69] Male Wistar rats after inducing colonic inflammation with TNBS Measurements on anesthetized animals and on blood samples and colon biopsies after administration of kynurenic acid Reduced inflammatory enzyme activities, decreased intestinal motility, and increased tone of the colon
Carpanese et al. [70] Enteric neuron cultures from adult male rats In vitro ischemic injury; reperfusion; blockage of glutamate receptors; Immuno-cytochemistry to measure cytotoxicity Blockade of glutamate receptors (NMDA and AMPA/kainite) may be neuroprotective
Forrest et al. [71] Patients with mild IBD Measured serum concentrations of purines and kynurenines Kynurenine modulation of glutamate receptors is involved in the symptoms of IBD