TY - JOUR AU - Burek, Patryk AU - Scherf, Nico AU - Herre, Heinrich PY - 2019 DA - 2019/10/16 TI - Ontology patterns for the representation of quality changes of cells in time JO - Journal of Biomedical Semantics SP - 16 VL - 10 IS - 1 AB - Cell tracking experiments, based on time-lapse microscopy, have become an important tool in biomedical research. The goal is the reconstruction of cell migration patterns, shape and state changes, and, comprehensive genealogical information from these data. This information can be used to develop process models of cellular dynamics. However, so far there has been no structured, standardized way of annotating and storing the tracking results, which is critical for comparative analysis and data integration. The key requirement to be satisfied by an ontology is the representation of a cell’s change over time. Unfortunately, popular ontology languages, such as Web Ontology Language (OWL), have limitations for the representation of temporal information. The current paper addresses the fundamental problem of modeling changes of qualities over time in biomedical ontologies specified in OWL. SN - 2041-1480 UR - https://doi.org/10.1186/s13326-019-0206-4 DO - 10.1186/s13326-019-0206-4 ID - Burek2019 ER -