Fig. 2

Illustration of OHMI ontology design pattern for representing host-microbiome interactions. The red box represents different levels of host-microbiome interactions. A specific example is the OHMI representation of a human-microbiome interaction in which the human host has the disease ankylosing spondylitis (AS). The human and microbiome classes are duplicated in this figure for clarity. Note that not every organism has the ‘host role’, and the role is here assigned to a host organism only in the case of host-microbiome interactions