Table 3 Assessment of the top 15 false-positive trajectories
From: Identifying disease trajectories with predicate information from a knowledge graph
First disease | ICD-10 | Second disease | ICD-10 | Assessment |
|---|---|---|---|---|
Mental and behavioural disorders due to use of alcohol | F10 | Alzheimer’s disease | G30 | Described in literature [37] |
Essential (primary) Hypertension | I10 | Alzheimer’s disease | G30 | Described in literature [38] |
Osteoporosis without pathological fracture | M81 | Alzheimer’s disease | G30 | Described in literature [39] |
Non-insulin-dependent diabetes mellitus | E11 | Alzheimer’s disease | G30 | Described in literature [40] |
Other disorders of pancreatic internal secretion | E16 | Alzheimer’s disease | G30 | Described in literature [41] |
Schizophrenia | F20 | Other septicaemia | A41 | Described in literature, but commonly occurs via intermediate diseases such as agranulocytosis and pneumonia [42] |
Lupus erythematosus | L93 | Other disorders of urinary system | N39 | Described in literature [43] |
Disorders of vestibular function | H81 | Alzheimer’s disease | G30 | Described in literature [44] |
Lupus erythematosus | L93 | Respiratory failure, not elsewhere classified | J96 | Described in literature [45] |
Unspecified Dementia | F03 | Dementia in Alzheimer’s Disease | F00 | Further specification of diagnosis |
Retinal vascular occlusions | H34 | Cystitis | N30 | No relationship found in literature |
Chronic ischaemic heart disease | I25 | Other septicaemia | A41 | Cardiac troponins are suggested to be biomarkers for sepsis [46] |
Hyperplasia of prostate | N40 | Alzheimer’s disease | G30 | No relationship found in literature |
Hyperparathyroidism and other disorders of parathyroid gland | E21 | Alzheimer’s disease | G30 | Suggested in literature (via calcium) [47] |
Asthma | J45 | Umbilical hernia | K42 | No relationship found in literature |