Table 4 Assessment of the top 15 false-negative trajectories
From: Identifying disease trajectories with predicate information from a knowledge graph
First disease | ICD-10 | Second disease | ICD-10 | Assessment |
|---|---|---|---|---|
Thyrotoxicosis [hyperthyroidism] | E05 | Other disorders of eye and adnexa | H57 | Likely side effect of treatment [48] |
Irritable bowel syndrome | K58 | Spondylosis | M47 | No relationship found in literature |
Vitamin B12 deficiency anaemia | D51 | Other septicaemia | A41 | Vitamin B12 has been hypothesized as treatment for sepsis [49] |
Mental and behavioural disorders due to use of alcohol | F10 | Acute and transient psychotic disorders | F23 | Described in literature, but no clear role for protein interactions [50] |
Gonarthrosis [arthrosis of knee] | M17 | Erysipelas | A46 | No relationship found in literature |
Senile cataract | H25 | Other disorders of lens | H27 | Likely side effect of treatment [51] |
Transient cerebral ischaemic attacks and related syndromes | G45 | Vitamin B12 deficiency anaemia | D51 | Only reverse described in literature, that vitamin B12 protects against stroke [52] |
Malignant neoplasm of ovary | C56 | Deficiency of other nutrient elements | E61 | Likely mechanical cause [53] |
Malignant neoplasm of larynx | C32 | Candidiasis | B37 | Likely side effect of treatment [54] |
Other intervertebral disc disorders | M51 | Somatoform disorders | F45 | No relationship found in literature |
Gonarthrosis [arthrosis of knee] | M17 | Other local infections of skin and subcutaneous tissue | L08 | No relationship found in literature |
Benign neoplasm of brain and other parts of central nervous system | D33 | Other septicaemia | A41 | Likely intermediate through infection, which follows surgery or weakening of the immune system after (radiation) treatment |
Insulin-dependent diabetes mellitus | E10 | Other disorders of eye and adnexa | H57 | Diabetes is a risk factor for many eye diseases [55], but it is not clear whether these fall under this ICD-10 code |
Noninflammatory disorders of ovary, fallopian tube and broad ligament | N83 | Ventral hernia | K43 | Likely side effect of treatment [56] |
Other intervertebral disc disorders | M51 | Other polyneuropathies | G62 | Likely mechanical cause [57] |