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Table 4 Assessment of the top 15 false-negative trajectories

From: Identifying disease trajectories with predicate information from a knowledge graph

First disease ICD-10 Second disease ICD-10 Assessment
Thyrotoxicosis [hyperthyroidism] E05 Other disorders of eye and adnexa H57 Likely side effect of treatment [48]
Irritable bowel syndrome K58 Spondylosis M47 No relationship found in literature
Vitamin B12 deficiency anaemia D51 Other septicaemia A41 Vitamin B12 has been hypothesized as treatment for sepsis [49]
Mental and behavioural disorders due to use of alcohol F10 Acute and transient psychotic disorders F23 Described in literature, but no clear role for protein interactions [50]
Gonarthrosis [arthrosis of knee] M17 Erysipelas A46 No relationship found in literature
Senile cataract H25 Other disorders of lens H27 Likely side effect of treatment [51]
Transient cerebral ischaemic attacks and related syndromes G45 Vitamin B12 deficiency anaemia D51 Only reverse described in literature, that vitamin B12 protects against stroke [52]
Malignant neoplasm of ovary C56 Deficiency of other nutrient elements E61 Likely mechanical cause [53]
Malignant neoplasm of larynx C32 Candidiasis B37 Likely side effect of treatment [54]
Other intervertebral disc disorders M51 Somatoform disorders F45 No relationship found in literature
Gonarthrosis [arthrosis of knee] M17 Other local infections of skin and subcutaneous tissue L08 No relationship found in literature
Benign neoplasm of brain and other parts of central nervous system D33 Other septicaemia A41 Likely intermediate through infection, which follows surgery or weakening of the immune system after (radiation) treatment
Insulin-dependent diabetes mellitus E10 Other disorders of eye and adnexa H57 Diabetes is a risk factor for many eye diseases [55], but it is not clear whether these fall under this ICD-10 code
Noninflammatory disorders of ovary, fallopian tube and broad ligament N83 Ventral hernia K43 Likely side effect of treatment [56]
Other intervertebral disc disorders M51 Other polyneuropathies G62 Likely mechanical cause [57]