Fig. 5
From: A comprehensive update on CIDO: the community-based coronavirus infectious disease ontology
Host-coronavirus protein-protein interactions (PPIs) and drugs targeting the viral or host proteins. A The hierarchy of PPIs, including ‘SARS-CoV-2 nsp5 protein binding to human HDAC2’. B The chemical nirmatrelvir (a component of the Pfizer drug Paxlovid) is an inhibitor of the virus protein nsp5 (i.e., 3C-like proteinase), which is critical for viral replication. C A chemical ‘Valproic Acid’ is an inhibitor of the HDAC2 (i.e., histone deacetylase 2). Valproic acid is also a valuable candidate against SARS-CoV-2