Workflow to annotate large sets of ESTs. Sequences are firstly annotated using high-throughput systems (e.g. Blast2GO, KAAS). Remaining difficult-to-annotate sequences are subsequently passed through ANNOTATOR for deeper analysis. The combined sequences are then joined with related annotations in the remote Ensembl database using BioMart and exposed through TogoDB such that they can be consumed by workflow managers (e.g. jORCA or Taverna) as TogoWS services.