Figure 4

Gene-vaccine interaction networks expanded with HPRD PPI. (A) The generic gene-gene interaction network derived from fever-related literature (Figure 2A) was compared against a protein-protein interaction network generated based on the HPRD. Interactions between genes in the two networks were compared, and 51 such interactions were common to both types of networks. (B) The HPRD PPI network was merged into the fever-associated gene-vaccine network (Figure 3) to create a comprehensive gene-gene-vaccine interaction network in the fever and vaccine domain. (C) A zoomed-in network illustrates the interactions around TNF-α and TNFRSF1A, and their interacting partners. Node colors (green = vaccine; red = genes; cyan = genes associated with vaccines), edge colors (yellow = common to both networks; black = literature-derived vaccine network only; green = HPRD only).