Table 2 Enriched disease and disorder categories in IPA analysis

Renal Inflammation

6.62E-09

VEGFA,COL4A5,CD40LG,APCS,IL1RN,CLU,MYH9,COL4A4,VDR,ACTN4,NFKB1,TNF,FAS

Renal Nephritis

6.62E-09

VEGFA,COL4A5,CD40LG,APCS,IL1RN,CLU,MYH9,COL4A4,VDR,ACTN4,NFKB1,TNF,FAS

Congenital Heart Anomaly

3.41E-06

VEGFA,HSPG2,TRIM21,EDNRA,ECE1

Liver Cirrhosis

4.13E-06

ADAM17,CD40LG,C5AR1,EDNRB,BSG,PTAFR,TNF,CCR7

Glomerular Injury

5.22E-06

VEGFA,CLU,MYH9,ACTN4

Cardiac Infarction

6.38E-06

PON1,BCL2L1,CD40LG,IL1RN,HSPA1A/HSPA1B,CLU,TNNI3,TNF,LRP1

Renal Atrophy

7.66E-06

CD40LG,EDNRB,FGF23,EDNRA,VDR,AQP2

Liver Damage

9.94E-06

BCL2L1,NLRP3,BSG,IL1RN,NFKB1,TNF,FAS

Liver Proliferation

1.75E-05

VEGFA,SOCS3,EDNRB,IL1RN,EDNRA,NFKB1,TNF,FAS

Pulmonary Hypertension

3.13E-05

EDNRB,IL1RN,KIT,EDNRA

Liver Hepatitis

4.73E-05

BCL2L1,IL23A,TNF,CCR7,FAS

Liver Necrosis/Cell Death

6.57E-05

SOCS3,BCL2L1,CD40LG,IL1RN,HSPD1,NFKB1,TNF,FAS

Cardiac Inflammation

6.64E-05

IL33,CLU,TNNI3,IL23A,NFKB1,TNF

Heart Failure

6.76E-05

BCL2L1,CA2,TNNI3,VDR,NFKB1,TNF,AQP2,PRKCA

Hepatocellular Carcinoma

6.87E-05

VEGFA,CA2,BCL2L1,SOCS3,ADAM17,BSG,KEAP1,CLU,IGFBP3,S100A4,KIT,MKI67,TNF

Liver Hyperplasia/Hyperproliferation

6.87E-05

VEGFA,CA2,BCL2L1,SOCS3,ADAM17,BSG,KEAP1,CLU,IGFBP3,S100A4,KIT,MKI67,TNF

Renal Dysfunction

2.46E-04

BSG,FGF23,TNF

Cardiac Necrosis/Cell Death

3.17E-04

VEGFA,SOCS3,BCL2L1,S100B,HSPD1,TNF,LRP1,NAD+

Cardiac Hypertrophy

5.67E-04

IL33,ADAM17,S100A6,HSPA1A/HSPA1B,FGF23,EDNRA,DMD,VDR,NFKB1,TNF,PRKCA

Renal Necrosis/Cell Death

5.83E-04

BCL2L1,HSPA1A/HSPA1B,IGFBP3,CLU,PAX2,NFKB1,TNF,FAS,PRKCA

Liver Inflammation

8.62E-04

IL1RN,FOXP3,NFKB1,TNF,FAS

Kidney Failure

1.37E-03

VEGFA,SLC9A3,PKD2,MYH9,VDR,TNF,AQP2

Cardiac Proliferation

1.66E-03

ADAM17,KIT,TNF,PRKCA

Renal Dilation

1.67E-03

EDNRB,EDNRA,AQP2

Nephrosis

2.35E-03

CLU,ACTN4

Liver Fibrosis

2.48E-03

VEGFA,SOCS3,EDNRB,PKD2,EDNRA,NFKB1,TNF,CCR7

Renal Proliferation

2.48E-03

SOCS3,HSPG2,TJP1,HSPD1,TNF,CCR7

Increased Levels of AST

3.13E-03

TNF,FAS

Cardiac Fibrosis

4.69E-03

TNNI3,DMD,VDR,NFKB1,TNF,DIO3

Increased Levels of Albumin

5.63E-03

VEGFA

Liver Regeneration

5.85E-03

SOCS3,IL1RN,TNF