CLO cell line design pattern and an example. (A) Generic CLO design pattern. Terms imported from external ontologies are displayed in blue boxes, while CLO-specific terms are displayed in yellow boxes. (B) An example of HeLa cell representation by applying CLO design pattern with extended information obtained from the BAO development (shown in dashed orange boxes) with details of culturing method, cell line modification, and STR profiling. Boxes represent instances, some labelled by the class they are an instance of. The relations used to link the boxes are instance-level relations. In several cases the parent class is also noted in the box using an is_a relation.