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Table 2 Significantly over-represented INO terms among the gene-gene interaction pairs of vaccine-associated sub-network

From: Development and application of an interaction network ontology for literature mining of vaccine-associated gene-gene interactions

INO_ID Reference term Enrichment fold BH * P-value Most frequent gene-pair (#)
INO_0000140 Neutralization 6.6 0 IFNG_IL12A (5)**
INO_0000096 induction of production 6.2 0 TNF_IFNG (2)
INO_0000106 gene fusion 5.6 0 CD40LG_CD40 (3)
INO_0000103 accessory regulation 3.9 0 CD8A_CD4 (55)
INO_0000062 Costimulation 3.7 0 CD40_CD8A (4)
INO_0000169 Synergization 3.0 0 CD8A_CD40 (5)
INO_0000089 co-regulation 2.9 0 CD8A_CD40 (5)
MI_0559 glycosylation reaction 2.9 0 IL17A_MUC6 (1)
MI_0195 covalent binding 2.5 0 CSF2_ACPP (2)
MI_0208 genetic interaction 4.9 1.82E-10 CD40LG_CD40 (3)
MI_0571 mRNA cleavage 23.2 2.58E-07 CFI_SUPT5H (1)
MI_0902 RNA cleavage 16.2 2.21E-06 CFI_SUPT5H (1)
MI_0910 nucleic acid cleavage 6.4 6.11E-04 CFI_SUPT5H (1)
GO_0018377 protein myristoylation 2.3 2.68E-03 CD4_S100B (2)
  1. *BH: Benjamini-Hochberg; **IFNG_IL12A (5): represents the IFNG and IL12A gene pair with the ‘neutralization’ interaction keyword in five papers.