Expanding the mammalian phenotype ontology to support automated exchange of high throughput mouse phenotyping data generated by large-scale mouse knockout screens

Table 2 Mouse genes with mutations causing pre- or perinatal lethality

	Genes with lethality annotation	Alleles with lethality annotation	Genes with lethality annotation and postnatal disease annotation
Prenatal lethality	2017	4393	611
Perinatal lethality	1076	2304	534
Both pre- and perinatal lethality	424	589	322
Total unique objects	2669	6108	823
Ratio of total objects annotated	2669/10014	6697/26894	823/10014

Numbers of mouse genes and alleles involved in genotypes annotated to prenatal or perinatal lethality MP terms in MGI as of 10/21/2014. The first column lists the number of genes with at least one allele in a genotype annotated to a prenatal lethality MP term or a perinatal lethality term. Some genes have multiple alleles annotated to either term set and some genes have one allele annotated to both term sets, possibly due to incomplete penetrance, genetic background differences or the nature of the mutant allele. The second column lists the total number of alleles in a genotype annotated to a prenatal lethality MP term or a perinatal lethality term. The third column lists the number of genes with additional disease annotations suggesting postnatal phenotypes.

ISSN: 2041-1480