Fig. 6

Ontological representation of an influenza microarray study. In this example, each of 28 human subjects was vaccinated once with an influenza vaccine [21]. At day 0, 3, and 7 post vaccination, human blood samples were extracted, peripheral blood mononuclear cell (PBMCs) were isolated from the blood samples, and RNAs were prepared from PBMCs. An Affymetrix microarray experiment was then conducted using the RNA samples. After RMA data normalization, the gene expression data from different groups (separated on the basis of time) were used for three types of statistical tests (ANOVA, S2N and SAM). All the boxes represent instances, labelled by the class names of these instances. All the relations are italicized