Fig. 2

Level of evidence to build the final decision (Rule-based final decisions). Inclusion conclusion (INC); Intermediate conclusion (ITC); Exclusion conclusion (EXC). Rule 1 (R1) and Rule (R2)—Strong evidence of a phenotype definition; Rule 3 (R3) and Rule 4 (R4)—Strong intermediate evidence of a phenotype definition; Rule 5 (R5) and Rule 6 (R6)—Weak intermediate evidence of a phenotype definition; and Rule 7 (R7)—No evidence of a phenotype definition