Table 2 Most significant GSEA clusters of Apicomplexans (P. falciparum and T. gondii) & Mastigophorans (T. cruzi). A full list of enrichment terms can be found in Supplemental Table 2
From: Ontological representation, modeling, and analysis of parasite vaccines
Species Gene Set | GO / UniProt Enrichment Term | # of antigens | Percentage | p-value | FDR |
|---|---|---|---|---|---|
T. gondii | Signal | 19 | 25.3 | 1.6E-07 | 9.6E-07 |
T. gondii | Toxoplasmosis | 7 | 9.3 | 3.9E-07 | 4.7E-06 |
T. gondii | Protein kinase | 7 | 9.3 | 3.9E-05 | 1.1E-03 |
P. falciparum | plasma membrane | 13 | 17.3 | 2.5E-14 | 9.9E-13 |
P. falciparum | Signal | 15 | 20.0 | 2.3E-07 | 1.4E-06 |
P. falciparum | entry into host | 9 | 12.0 | 9.9E-09 | 2.5E-07 |
P. falciparum | Anchored component of plasma membrane | 4 | 5.3 | 4.4E-05 | 3.4E-04 |
P. falciparum | Malaria | 9 | 12.0 | 4.0E-04 | 4.0E-03 |
T. cruzi | motile cilium | 2 | 5.3 | 9.6E-03 | 4.8E-02 |
T. cruzi | Chagas disease | 2 | 5.3 | 3.5E-02 | 3.5E-02 |