Table 1 Possible outcomes of a dual analysis process
From: Reporting phenotypes in mouse models when considering body size as a potential confounder
Row | A1 | A2: + weight | Conclusion | Insight |
|---|---|---|---|---|
1 | + | - | Absolute phenotype ∆ | No longer significant–confounded by BW |
2 | - | - | No abnormality | |
3 | - | + | Relative phenotype ∆ | Adding weight increases sensitivity to detect ∆ |
4 | + | + | Absolute phenotype ∆ and relative phenotype ∆ | Two scenarios |
1. BW difference: still there is a significant ∆ as ∆ larger/smaller than expect for BW difference | ||||
2. BW same: a significant ∆. Weight explains variation but does not lead to phenotype difference. |