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Vaccine and drug ontology in the study of mechanism and effect 2012 (VDOSME)

Vaccines and drugs have been critical to prevent and treat human and animal diseases. Vaccines and drugs are closely related in various aspects such as preclinical research and development, manufacturing, clinical trials, government approval and regulation, and post-licensure usage surveillance and monitoring. In a broader scope, vaccine is a special type of drug. Over the last decade, there have been efforts in biomedical ontology that represent various areas associated with vaccines and drugs, which join existing health and clinical terminology systems (e.g., SNOMED, RxNorm, NDF-RT, and MedDRA) in their applications to research and clinical data. This thematic series aims to provide a platform for discussing problems and solutions in the development and applications of biomedical ontologies to representing and analyzing vaccines/drugs, vaccine/drug administrations, vaccine/drug-induced immune responses, adverse events, and similar topics. Different computational methods, including literature mining of vaccine/drug-gene interaction networks, meta-analysis of host immune responses, time event analysis of adverse events, and Semantic Web applications, have been applied.

Prof Darrell Abernethy, Dr Gully Burns, Dr Yongqun He, Dr Cui Tao, Dr Luca Toldo

  1. Fever is one of the most common adverse events of vaccines. The detailed mechanisms of fever and vaccine-associated gene interaction networks are not fully understood. In the present study, we employed a genom...

    Authors: Junguk Hur, Arzucan Özgür, Zuoshuang Xiang and Yongqun He
    Citation: Journal of Biomedical Semantics 2012 3:18
  2. Structured Product Labeling (SPL) is a document markup standard approved by Health Level Seven (HL7) and adopted by United States Food and Drug Administration (FDA) as a mechanism for exchanging drug product i...

    Authors: Qian Zhu, Guoqian Jiang and Christopher G Chute
    Citation: Journal of Biomedical Semantics 2012 3:16
  3. The sheer amount of information about potential adverse drug events publishedin medical case reports pose major challenges for drug safety experts toperform timely monitoring. Efficient strategies for identifi...

    Authors: Harsha Gurulingappa, Abdul Mateen‐Rajpu and Luca Toldo
    Citation: Journal of Biomedical Semantics 2012 3:15
  4. Identification of drug-drug and drug-diseases interactions can pose a difficult problem to cope with, as the increasingly large number of available drugs coupled with the ongoing research activities in the pha...

    Authors: Charalampos Doulaverakis, George Nikolaidis, Athanasios Kleontas and Ioannis Kompatsiaris
    Citation: Journal of Biomedical Semantics 2012 3:14
  5. The U.S. FDA/CDC Vaccine Adverse Event Reporting System (VAERS) provides a valuable data source for post-vaccination adverse event analyses. The structured data in the system has been widely used, but the info...

    Authors: Cui Tao, Yongqun He, Hannah Yang, Gregory A Poland and Christopher G Chute
    Citation: Journal of Biomedical Semantics 2012 3:13
  6. Vaccines and drugs have contributed to dramatic improvements in public health worldwide. Over the last decade, there have been efforts in developing biomedical ontologies that represent various areas associate...

    Authors: Yongqun He, Luca Toldo, Gully Burns, Cui Tao and Darrell R Abernethy
    Citation: Journal of Biomedical Semantics 2012 3:12

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