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  1. Mild traumatic brain injury (mTBI) has high prevalence in the military, among athletes, and in the general population worldwide (largely due to falls). Consequences can include a range of neuropsychological di...

    Authors: Michael J Cairelli, Marcelo Fiszman, Han Zhang and Thomas C Rindflesch
    Citation: Journal of Biomedical Semantics 2015 6:25
  2. While the association between a drug and an adverse event (ADE) is generally detected at the level of individual drugs, ADEs are often discussed at the class level, i.e., at the level of pharmacologic classes ...

    Authors: Rainer Winnenburg, Alfred Sorbello and Olivier Bodenreider
    Citation: Journal of Biomedical Semantics 2015 6:18
  3. Lately, ontologies have become a fundamental building block in the process of formalising and storing complex biomedical information. The community-driven ontology curation process, however, ignores the possib...

    Authors: Tudor Groza, Tania Tudorache, Peter N Robinson and Andreas Zankl
    Citation: Journal of Biomedical Semantics 2015 6:21
  4. Model repositories such as BioModels Database provide computational models of biological systems for the scientific community. These models contain rich semantic annotations that link model entities to concept...

    Authors: Rebekka Alm, Dagmar Waltemath, Markus Wolfien, Olaf Wolkenhauer and Ron Henkel
    Citation: Journal of Biomedical Semantics 2015 6:20
  5. Establishing robust links among gene expression, pathways and phenotypes is critical for understanding diseases and developing treatments. In recent years there have been many efforts to develop the computatio...

    Authors: Irene Papatheodorou, Anika Oellrich and Damian Smedley
    Citation: Journal of Biomedical Semantics 2015 6:17
  6. There is an increasing recognition of the need for the data capture phase of clinical studies to be improved and for more effective sharing of clinical data. The Health Care and Life Sciences community has emb...

    Authors: Hugo Leroux and Laurent Lefort
    Citation: Journal of Biomedical Semantics 2015 6:16
  7. Electronic Health Records (EHRs) contain a wealth of information useful for studying clinical phenotype-genotype relationships. Severity is important for distinguishing among phenotypes; however other severity...

    Authors: Mary Regina Boland, Nicholas P Tatonetti and George Hripcsak
    Citation: Journal of Biomedical Semantics 2015 6:14
  8. Ontologies play a major role in life sciences, enabling a number of applications, from new data integration to knowledge verification. SNOMED CT is a large medical ontology that is formally defined so that it ...

    Authors: Alina Petrova, Yue Ma, George Tsatsaronis, Maria Kissa, Felix Distel, Franz Baader and Michael Schroeder
    Citation: Journal of Biomedical Semantics 2015 6:22
  9. We develop medical-specialty specific ontologies that contain the settled science and common term usage. We leverage current practices in information and relationship extraction to streamline the ontology deve...

    Authors: Kristina Doing-Harris, Yarden Livnat and Stephane Meystre
    Citation: Journal of Biomedical Semantics 2015 6:15
  10. The NDF-RT (National Drug File Reference Terminology) is an ontology, which describes drugs and their properties and supports computerized physician order entry systems. NDF-RT’s classes are mostly specified u...

    Authors: Rainer Winnenburg, Jonathan M Mortensen and Olivier Bodenreider
    Citation: Journal of Biomedical Semantics 2015 6:13
  11. With the increasing presence of biomedical data sources on the Internet more and more research effort is put into finding possible ways for integrating and searching such often heterogeneous sources. Ontologie...

    Authors: Patrick Lambrix, Fang Wei-Kleiner and Zlatan Dragisic
    Citation: Journal of Biomedical Semantics 2015 6:12
  12. A vast array of data is about to emerge from the large scale high-throughput mouse knockout phenotyping projects worldwide. It is critical that this information is captured in a standardized manner, made acces...

    Authors: Cynthia L Smith and Janan T Eppig
    Citation: Journal of Biomedical Semantics 2015 6:11
  13. Engineered nanomaterials (ENMs) are being developed to meet specific application needs in diverse domains across the engineering and biomedical sciences (e.g. drug delivery). However, accompanying the exciting...

    Authors: Janna Hastings, Nina Jeliazkova, Gareth Owen, Georgia Tsiliki, Cristian R Munteanu, Christoph Steinbeck and Egon Willighagen
    Citation: Journal of Biomedical Semantics 2015 6:10
  14. Most computational methods that predict protein function do not take advantage of the large amount of information contained in the biomedical literature. In this work we evaluate both ontology term co-mention ...

    Authors: Christopher S Funk, Indika Kahanda, Asa Ben-Hur and Karin M Verspoor
    Citation: Journal of Biomedical Semantics 2015 6:9
  15. Chronic obstructive pulmonary disease (COPD) is a life-threatening lung disorder whose recent prevalence has led to an increasing burden on public healthcare. Phenotypic information in electronic clinical reco...

    Authors: Xiao Fu, Riza Batista-Navarro, Rafal Rak and Sophia Ananiadou
    Citation: Journal of Biomedical Semantics 2015 6:8
  16. As the availability of open access full text research articles increases, so does the need for sophisticated search services that make the most of this new content. Here, we present a new feature available in ...

    Authors: Şenay Kafkas, Xingjun Pi, Nikos Marinos, Francesco Talo’, Andrew Morrison and Johanna R McEntyre
    Citation: Journal of Biomedical Semantics 2015 6:7
  17. Semantic similarity measures over phenotype ontologies have been demonstrated to provide a powerful approach for the analysis of model organism phenotypes, the discovery of animal models of human disease, nove...

    Authors: Robert Hoehndorf, Michael Gruenberger, Georgios V Gkoutos and Paul N Schofield
    Citation: Journal of Biomedical Semantics 2015 6:6
  18. Data from high throughput experiments often produce far more results than can ever appear in the main text or tables of a single research article. In these cases, the majority of new associations are often arc...

    Authors: Eleni Mina, Mark Thompson, Rajaram Kaliyaperumal, Jun Zhao, van Eelke der Horst, Zuotian Tatum, Kristina M Hettne, Erik A Schultes, Barend Mons and Marco Roos
    Citation: Journal of Biomedical Semantics 2015 6:5
  19. It is time-consuming to build an ontology with many terms and axioms. Thus it is desired to automate the process of ontology development. Ontology Design Patterns (ODPs) provide a reusable solution to solve a ...

    Authors: Zuoshuang Xiang, Jie Zheng, Yu Lin and Yongqun He
    Citation: Journal of Biomedical Semantics 2015 6:4
  20. Linked Data has gained some attention recently in the life sciences as an effective way to provide and share data. As a part of the Semantic Web, data are linked so that a person or machine can explore the web...

    Authors: Kiyoko F Aoki-Kinoshita, Akira R Kinjo, Mizuki Morita, Yoshinobu Igarashi, Yi-an Chen, Yasumasa Shigemoto, Takatomo Fujisawa, Yukie Akune, Takeo Katoda, Anna Kokubu, Takaaki Mori, Mitsuteru Nakao, Shuichi Kawashima, Shinobu Okamoto, Toshiaki Katayama and Soichi Ogishima
    Citation: Journal of Biomedical Semantics 2015 6:3
  21. Literature mining of gene-gene interactions has been enhanced by ontology-based name classifications. However, in biomedical literature mining, interaction keywords have not been carefully studied and used bey...

    Authors: Junguk Hur, Arzucan Özgür, Zuoshuang Xiang and Yongqun He
    Citation: Journal of Biomedical Semantics 2015 6:2
  22. In this study, we present an analysis of data citation practices in full text research articles and their corresponding supplementary data files, made available in the Open Access set of articles from Europe P...

    Authors: Şenay Kafkas, Jee-Hyub Kim, Xingjun Pi and Johanna R McEntyre
    Citation: Journal of Biomedical Semantics 2015 6:1
  23. Using knowledge representation for biomedical projects is now commonplace. In previous work, we represented the knowledge found in a college-level biology textbook in a fashion useful for answering questions. ...

    Authors: Vinay K Chaudhri, Daniel Elenius, Andrew Goldenkranz, Allison Gong, Maryann E Martone, William Webb and Neil Yorke-Smith
    Citation: Journal of Biomedical Semantics 2014 5:51
  24. Large quantities of digital images are now generated for biological collections, including those developed in projects premised on the high-throughput screening of genome-phenome experiments. These images ofte...

    Authors: Nikhil Tej Lingutla, Justin Preece, Sinisa Todorovic, Laurel Cooper, Laura Moore and Pankaj Jaiswal
    Citation: Journal of Biomedical Semantics 2014 5:50
  25. In this paper, we show how we have applied the Clinical Narrative Temporal Relation Ontology (CNTRO) and its associated temporal reasoning system (the CNTRO Timeline Library) to trend temporal information with...

    Authors: Kim Clark, Deepak Sharma, Rui Qin, Christopher G Chute and Cui Tao
    Citation: Journal of Biomedical Semantics 2014 5:49
  26. Biological ontologies are continually growing and improving from requests for new classes (terms) by biocurators. These ontology requests can frequently create bottlenecks in the biocuration process, as ontolo...

    Authors: Heiko Dietze, Tanya Z Berardini, Rebecca E Foulger, David P Hill, Jane Lomax, David Osumi-Sutherland, Paola Roncaglia and Christopher J Mungall
    Citation: Journal of Biomedical Semantics 2014 5:48
  27. The Cancer Genome Atlas (TCGA) is a multidisciplinary, multi-institutional effort to catalogue genetic mutations responsible for cancer using genome analysis techniques. One of the aims of this project is to c...

    Authors: Muhammad Saleem, Shanmukha S Padmanabhuni, Axel-Cyrille Ngonga Ngomo, Aftab Iqbal, Jonas S Almeida, Stefan Decker and Helena F Deus
    Citation: Journal of Biomedical Semantics 2014 5:47
  28. Two distinct trends are emerging with respect to how data is shared, collected, and analyzed within the bioinformatics community. First, Linked Data, exposed as SPARQL endpoints, promises to make data easier t...

    Authors: Alejandro Rodríguez González, Alison Callahan, José Cruz-Toledo, Adrian Garcia, Mikel Egaña Aranguren, Michel Dumontier and Mark D Wilkinson
    Citation: Journal of Biomedical Semantics 2014 5:46
  29. Phenex (http://​phenex.​phenoscape.​org/​) is a desktop application for semantically annotating the phenotypic character matrix datasets common in evolutio...

    Authors: James P Balhoff, Wasila M Dahdul, T Alexander Dececchi, Hilmar Lapp, Paula M Mabee and Todd J Vision
    Citation: Journal of Biomedical Semantics 2014 5:45
  30. We are currently facing a proliferation of heterogeneous biomedical data sources accessible through various knowledge-based applications. These data are annotated by increasingly extensive and widely dissemina...

    Authors: Gayo Diallo
    Citation: Journal of Biomedical Semantics 2014 5:44
  31. Bacterial identification and characterization at subspecies level is commonly known as Microbial Typing. Currently, these methodologies are fundamental tools in Clinical Microbiology and bacterial population g...

    Authors: Cátia Vaz, Alexandre P Francisco, Mickael Silva, Keith A Jolley, James E Bray, Hannes Pouseele, Joerg Rothganger, Mário Ramirez and João A Carriço
    Citation: Journal of Biomedical Semantics 2014 5:43
  32. In recent years Galaxy has become a popular workflow management system in bioinformatics, due to its ease of installation, use and extension. The availability of Semantic Web-oriented tools in Galaxy, however,...

    Authors: Mikel Egaña Aranguren, Alejandro Rodríguez González and Mark D Wilkinson
    Citation: Journal of Biomedical Semantics 2014 5:42
  33. One of the main challenges for biomedical research lies in the computer-assisted integrative study of large and increasingly complex combinations of data in order to understand molecular mechanisms. The preser...

    Authors: Kristina M Hettne, Harish Dharuri, Jun Zhao, Katherine Wolstencroft, Khalid Belhajjame, Stian Soiland-Reyes, Eleni Mina, Mark Thompson, Don Cruickshank, Lourdes Verdes-Montenegro, Julian Garrido, David de Roure, Oscar Corcho, Graham Klyne, Reinout van Schouwen, Peter A C ‘t Hoen…
    Citation: Journal of Biomedical Semantics 2014 5:41
  34. The scientific names of plants and animals play a major role in Life Sciences as information is indexed, integrated, and searched using scientific names. The main problem with names is their ambiguous nature, ...

    Authors: Nina Laurenne, Jouni Tuominen, Hannu Saarenmaa and Eero Hyvönen
    Citation: Journal of Biomedical Semantics 2014 5:40
  35. Porifera (sponges) are ancient basal metazoans that lack organs. They provide insight into key evolutionary transitions, such as the emergence of multicellularity and the nervous system. In addition, their abi...

    Authors: Robert W Thacker, Maria Cristina Díaz, Adeline Kerner, Régine Vignes-Lebbe, Erik Segerdell, Melissa A Haendel and Christopher J Mungall
    Citation: Journal of Biomedical Semantics 2014 5:39
  36. We evaluate the application of the Emotion Ontology (EM) to the task of self-reporting of emotional experience in the context of audience response to academic presentations at the International Conference on B...

    Authors: Janna Hastings, Andy Brass, Colin Caine, Caroline Jay and Robert Stevens
    Citation: Journal of Biomedical Semantics 2014 5:38
  37. Cell lines have been widely used in biomedical research. The community-based Cell Line Ontology (CLO) is a member of the OBO Foundry library that covers the domain of cell lines. Since its publication two year...

    Authors: Sirarat Sarntivijai, Yu Lin, Zuoshuang Xiang, Terrence F Meehan, Alexander D Diehl, Uma D Vempati, Stephan C Schürer, Chao Pang, James Malone, Helen Parkinson, Yue Liu, Terue Takatsuki, Kaoru Saijo, Hiroshi Masuya, Yukio Nakamura, Matthew H Brush…
    Citation: Journal of Biomedical Semantics 2014 5:37
  38. The Adverse Event Reporting System (AERS) is an FDA database providing rich information on voluntary reports of adverse drug events (ADEs). Normalizing data in the AERS would improve the mining capacity of the...

    Authors: Liwei Wang, Guoqian Jiang, Dingcheng Li and Hongfang Liu
    Citation: Journal of Biomedical Semantics 2014 5:36
  39. Spatial terminology is used in anatomy to indicate precise, relative positions of structures in an organism. While these terms are often standardized within specific fields of biology, they can differ dramatic...

    Authors: Wasila M Dahdul, Hong Cui, Paula M Mabee, Christopher J Mungall, David Osumi-Sutherland, Ramona L Walls and Melissa A Haendel
    Citation: Journal of Biomedical Semantics 2014 5:34
  40. A huge amount of associations among different biological entities (e.g., disease, drug, and gene) are scattered in millions of biomedical articles. Systematic analysis of such heterogeneous data can infer nove...

    Authors: Yuji Zhang, Cui Tao, Guoqian Jiang, Asha A Nair, Jian Su, Christopher G Chute and Hongfang Liu
    Citation: Journal of Biomedical Semantics 2014 5:33
  41. Biological databases vary enormously in size and data complexity, from small databases that contain a few million Resource Description Framework (RDF) triples to large databases that contain billions of triple...

    Authors: Hongyan Wu, Toyofumi Fujiwara, Yasunori Yamamoto, Jerven Bolleman and Atsuko Yamaguchi
    Citation: Journal of Biomedical Semantics 2014 5:32
  42. In the past years, significant progress has been made to develop and use experimental settings for extensive data collection on tobacco smoke exposure and tobacco smoke exposure-associated diseases. Due to the...

    Authors: Erfan Younesi, Sam Ansari, Michaela Guendel, Shiva Ahmadi, Chris Coggins, Julia Hoeng, Martin Hofmann-Apitius and Manuel C Peitsch
    Citation: Journal of Biomedical Semantics 2014 5:31
  43. A medical intervention is a medical procedure or application intended to relieve or prevent illness or injury. Examples of medical interventions include vaccination and drug administration. After a medical int...

    Authors: Yongqun He, Sirarat Sarntivijai, Yu Lin, Zuoshuang Xiang, Abra Guo, Shelley Zhang, Desikan Jagannathan, Luca Toldo, Cui Tao and Barry Smith
    Citation: Journal of Biomedical Semantics 2014 5:29
  44. Scientific publications are documentary representations of defeasible arguments, supported by data and repeatable methods. They are the essential mediating artifacts in the ecosystem of scientific communicatio...

    Authors: Tim Clark, Paolo N Ciccarese and Carole A Goble
    Citation: Journal of Biomedical Semantics 2014 5:28
  45. With the advent of inexpensive assay technologies, there has been an unprecedented growth in genomics data as well as the number of databases in which it is stored. In these databases, sample annotation using ...

    Authors: Emily Merrill, Stéphane Corlosquet, Paolo Ciccarese, Tim Clark and Sudeshna Das
    Citation: Journal of Biomedical Semantics 2014 5(Suppl 1):S3

    This article is part of a Supplement: Volume 5 Supplement 1

  46. Over the 16 years, the Bio-Ontologies SIG at ISMB has provided a forum for vibrant discussions of the latest and most innovative advances in the research area of bio-ontologies, its applications to biomedicine...

    Authors: Larisa N Soldatova, Philippe Rocca-Serra, Michel Dumontier and Nigam H Shah
    Citation: Journal of Biomedical Semantics 2014 5(Suppl 1):I1

    This article is part of a Supplement: Volume 5 Supplement 1

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